Method for producing no-carrier-added {sup 161}Tb
- Univ. of Missouri, Columbia, MO (United States)
Much progress has been made in tumor-imaging techniques [single photon emission computed tomography (SPECT) positron emission tomography etc.] using radiopharmaceuticals over the last decade. Detection sensitivity can be improved by physically placing a detector close to the radioactively tagged tumor. Recently, hand-held gamma-detecting probes (GDPs) have been used directly over the source of gamma emission during the surgical procedure for identifying tumors and malignancies. The development of small surgical guidance probes for insertion into the body for very small tumor detection will assist surgeons in intraoperative decision making by identifying residual tumors and then allowing complete surgical resection. It is reported that such probes have detected tumors <1 cm in diameter. Using a GDP as a surgical guide is efficient, reliable, and of clinical relevance, allowing otherwise undetectable small, deep-lying neoplastic lesions to be surgically removed. However, the radionuclides currently used for diagnosis in SPECT, such as {sup 99m}Tc and {sup 11}In, are not ideal for intraoperative GDP due to their relatively hard gamma rays, which will generate high background from surrounding tissue uptake. Gamma rays with low energy have less penetration and will reduce background from nontumor accumulations. For this reason, there is increasing interest in finding radionuclides that are more suitable for intraoperative GDP. Terbium-161 is considered a suitable radionuclide for intraoperative GDP applications and is currently under investigation. It emits low-energy gamma rays (46 to 48 and 74 keV) and decays with a half-life of 6.91 days, which make it ideal for intraoperative GDP. This paper describes the production of terbium-161.
- OSTI ID:
- 436878
- Report Number(s):
- CONF-9606116-; ISSN 0003-018X; TRN: 96:005275-0109
- Journal Information:
- Transactions of the American Nuclear Society, Vol. 74; Conference: Annual meeting of the American Nuclear Society (ANS), Reno, NV (United States), 16-20 Jun 1996; Other Information: PBD: 1996
- Country of Publication:
- United States
- Language:
- English
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