Defense of Cutaneous Cells Against Uv Irradiation. II. Restricted Photomediated Binding of Trimethyl Psoralen to Pigmented Skin in Vivo
Journal Article
·
· Journal of Investigative Dermatology
Distinct differences in grain distribution were seen in autoradiographs of pigmented and nonpigmented skin from spotted guinea-pig ears subjected to photosensitizing conditions by the topical application of tritiated trimethylpsoralen FH-TMP) and exposure to uv irradiation at 365 nm. Grains were localized over cells throughout the epidermis in nonpigmented skin, but they were not seen beneath the stratum corneum in pigmented skin. Since TMP covalently binds to epidermal nucleic acids only after irradiation, these experiments demonstrate that the compacted melanized cells of the outer epidermis shield the DNA of underlying cells by severely restricting the penetration of uv light into the skin.
- Research Organization:
- Yale Univ., New Haven
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-29-008013
- OSTI ID:
- 4367822
- Journal Information:
- Journal of Investigative Dermatology, Journal Name: Journal of Investigative Dermatology Journal Issue: 5 Vol. 60; ISSN 0022-202X
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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