Neoplasms in Rats Protected Against Lethal Doses of Irradiation by Parabiosis or PARA-Aminopropiophenone

Technical Report · Tue Oct 20 04:00:00 EST 1953

DOI:https://doi.org/10.2172/4365714· OSTI ID:4365714

Brecher, George ^[1]; Cronkite, E. P. ^[2]; Peers, J. H. ^[1]

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1. National Institutes of Health (NIH), Bethesda, MD (United States). National Institute of Arthritis and Metabolic Diseases
2. Naval Medical Research Institute, Bethesda, MD (United States). National Naval Medical Center

Rats that survived otherwise lethal doses of radiation when protected by para-aminopropriophenone or parabiosis are followed along with their normal controls for the rest of their natural lives. Seventy animals have been irradiated. Of these, 22 have survived 6 months or more and in these survivors there has appeared an adamantinoma, renal carcinoma, sarcoma, adenocarcinoma of the duodenum, jejuneum, and of the ileum, glioma and adenocarcinoma of colon; and a uterine sarcoma between 6 and 16 months after irradiation. During this time no tumors have developed in control animals. The high incidence of tumors in this small group of animals, and the incidence of tumor types that seldom occur spontaneously, indicate that these neoplasms were induced by whole-body irradiation.

• Research Organization: Naval Medical Research Institute, Bethesda, MD (United States). Naval Medical Center
• Sponsoring Organization: US Navy; National Institutes of Health (NIH)
• NSA Number: NSA-10-001165
• OSTI ID: 4365714
• Report Number(s): NM--006.012.05.12
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.