TUMORS AND DEVELOPMENTAL ANOMALIES IN WISTAR RATS IN THE FIRST GENERATION AFTER MATERNAL WHOLE-BODY IRRADIATION WITH 270 r ON THE 18th DAY OF GESTATION
Journal Article
·
· Beitr. Pathol. Anat. Allgem. Pathol.
OSTI ID:4746533
On the 18th day of pregnancy, 47 rats were irradiated with 180-kv x rays and the 147 surviving offspring were examined throughout life for evidence of radioinduced effects. Of the 1st generation offspring, 25% developed malignant or benign tumors 12 months or later after irradiation in utero. The death rate from tumors reached a maximum after 23 months and another, higher maximum after 29 months. The tumors were principally sarcomas of various degrees of differentiation, adenocarcinomas of uterus, ovary, kidney, and small intestine, squamous cell carcinomas of skin, pheochromocytoma of adrenal, pancreatic islet- cell adenomas, and Leydig-cell tumors of testis. In 92% of the rats studied, anomalies of the central nervous system, of varying degrees of severity, were noted, ranging from microencephaly with incomplete formation of corpus callosum to anencephaly. Large-chambered renal cysts were found in 4.7%. Rats with brain defects often were dwarfed and showed diminished vitality. The absence of mammary tumors in the rats, in contrast to findings in control animals and animals irradiated at other stages of life, may be attributed to ovarian atrophy. In 26% of the irradiated mother rats, tumors were observed, principally mammary fibroadenomas and uterine polyps. The same incidence (23 to 30%) was found in young rats irradiated with a single 270-r x-ray dose on the 13 to 49th day of life. (H.H.D.)
- Research Organization:
- Universitat, Freiburg i. B.
- NSA Number:
- NSA-17-017811
- OSTI ID:
- 4746533
- Journal Information:
- Beitr. Pathol. Anat. Allgem. Pathol., Journal Name: Beitr. Pathol. Anat. Allgem. Pathol. Vol. Vol: 124
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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