Late effects of irradiation on the thyroid gland in mice. 2. Irradiation of mouse foetuses

Journal Article · Fri Dec 01 04:00:00 EST 1972 · Acta Radiol., Ther., Phys., Biol., v. 11, no. 6, pp. 577-589

DOI:https://doi.org/10.3109/02841867209129803· OSTI ID:4362540

Walinder, G; Sjoeden, A M

The thyroid gland of mouse fetuses was irradiated by exposing the mothers on the 18th day of gestation to intravenous injections of /sup 131/I, whole-body roentgen irradiation, or a combination of the two forms of radiation. The occurrence of thyroid tumors was investigated when the offspring had reached the age of about 2 years. The frequency of both benign and malignant thyroid tumors was high. As the aging thyroids of the unirradiated mice revealed adenomatous changes to an extent that had not been seen in earlier investigations the high frequency of tumors in the irradiated thyroids could not be attributed unequivocally to any special radiation sensitivity in the fetal glands. The significance of the growth factors in the development of radiation-induced thyroid neoplasms is discussed. (auth)

• Research Organization: Foersvarets Forskningsanstalt, Stockholm
• NSA Number: NSA-29-010449
• OSTI ID: 4362540
• Journal Information: Acta Radiol., Ther., Phys., Biol., v. 11, no. 6, pp. 577-589, Journal Name: Acta Radiol., Ther., Phys., Biol., v. 11, no. 6, pp. 577-589; ISSN ATHBA
• Country of Publication: Sweden
• Language: English

Related Subjects

*FETUSES-- PRENATAL IRRADIATION
*THYROID-- DELAYED RADIATION EFFECTS
INTRAVENOUS INJECTION
IODINE 131
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
N48620 --Life Sciences--Radionuclide Effects (Internal Source)--Animals
NEOPLASMS
PHOTON BEAMS
WHOLE-BODY IRRADIATION
X RADIATION