Radiosensitization of phosphate release from 3'- and 5'-nucleotides: correlations between chemical change and biological inactivation

Journal Article · Sat Dec 01 04:00:00 EST 1973 · Int. J. Radiat. Biol., v. 24, no. 6, pp. 595-603

DOI:https://doi.org/10.1080/09553007314551511· OSTI ID:4358899

Raleigh, J A; Greenstock, C L; Whitehouse, R; Kremers, W

The effect of nitrobenzene radiosensitizers on the release of inorganic phosphate in aqueous solutions of 3'- and 5'-nucleotides in the absence of oxygen was quite specific. The 5'-purine nucleotides were sensitized, whereas both 3'- purine and -pyrimidine nucleotides were protected. Sensitization and protection increased with increasing nitrobenzene electron affinity and concentration. The 5'-pyrimidine nucleotides could be protected or sensitized, depending on sensitizer electron affinity and concertration. Correlations between enhancement ratios for chemical and biological damage (Chinese-hamster cell killing in hypoxia) are examined, with a view to relating radiation chemical change in cellular molecules to biological inactivation. (auth)

• Research Organization: Atomic Energy of Canada Ltd., Pinawa, Manitoba
• NSA Number: NSA-29-015840
• OSTI ID: 4358899
• Journal Information: Int. J. Radiat. Biol., v. 24, no. 6, pp. 595-603, Journal Name: Int. J. Radiat. Biol., v. 24, no. 6, pp. 595-603; ISSN IJRBA
• Country of Publication: United Kingdom
• Language: English

Related Subjects

*NITROBENZENE-- RADIOSENSITIVITY EFFECTS
*NUCLEOTIDES-- RADIOSENSITIVITY
ANIMAL CELLS
ANOXIA
AQUEOUS SOLUTIONS
BIOLOGICAL RADIATION EFFECTS
HAMSTERS
INACTIVATION
N48110* --Life Sciences--Radiation Effects on Biochemicals-- In-Vitro
N48210 --Life Sciences--Radiation Effects on Cells--External Source
OXYGEN
PHOSPHATES
PURINES
PYRIMIDINES
RADICALS
RADIOSENSITIZERS