Inactivation of Chinese hamsters cells by x rays: the effects of chemical modifiers on single- and double-events
The radiation inactivation of the proliferative capacity of Chinese hamster fibroblasts is described by the linear--quadratic relationship, S/S$sub 0$ = exp (-$alpha$D - $beta$$D$$sup 2$). Values of $alpha$ and $beta$ have been determined for asynchronous cells irradiated under various conditions of chemical radioprotection and radiosensitization. OH has been found to contribute to cell inactivation by both $alpha$ (single-events) and $beta$ (double-events). Sulfhydryl repair was found to provide radioprotection against single- and double- events while molecular oxygen was found to radiosensitize predominantly by enhancing double-events. Electron-affinic radiosensitizers enhanced the double- event component. These radiation chemical effects on cell inactivation are discussed with reference to potential molecular targets and lesions and the microdosimetry of 250 kV X rays in water. (auth)
- Research Organization:
- Atomic Energy of Canada Ltd., Pinawa, Manitoba
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-33-017315
- OSTI ID:
- 4120821
- Journal Information:
- Radiat. Res., v. 64, no. 2, pp. 365-375, Journal Name: Radiat. Res., v. 64, no. 2, pp. 365-375; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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