Inactivation of Chinese hamsters cells by x rays: the effects of chemical modifiers on single- and double-events

Journal Article · Sat Nov 01 04:00:00 EST 1975 · Radiat. Res., v. 64, no. 2, pp. 365-375

DOI:https://doi.org/10.2307/3574272· OSTI ID:4120821

Chapman, J D; Gillespie, C J; Reuvers, A P; Dugle, D L

The radiation inactivation of the proliferative capacity of Chinese hamster fibroblasts is described by the linear--quadratic relationship, S/S$sub 0$ = exp (-$alpha$D - $beta$$D$$sup 2$). Values of $alpha$ and $beta$ have been determined for asynchronous cells irradiated under various conditions of chemical radioprotection and radiosensitization. OH has been found to contribute to cell inactivation by both $alpha$ (single-events) and $beta$ (double-events). Sulfhydryl repair was found to provide radioprotection against single- and double- events while molecular oxygen was found to radiosensitize predominantly by enhancing double-events. Electron-affinic radiosensitizers enhanced the double- event component. These radiation chemical effects on cell inactivation are discussed with reference to potential molecular targets and lesions and the microdosimetry of 250 kV X rays in water. (auth)

• Research Organization: Atomic Energy of Canada Ltd., Pinawa, Manitoba
• Sponsoring Organization: USDOE
• NSA Number: NSA-33-017315
• OSTI ID: 4120821
• Journal Information: Radiat. Res., v. 64, no. 2, pp. 365-375, Journal Name: Radiat. Res., v. 64, no. 2, pp. 365-375; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

*ANIMAL CELLS-- INACTIVATION
*HYDROXYL RADICALS-- RADIOSENSITIVITY EFFECTS
*INACTIVATION-- MATHEMATICAL MODELS
*OXYGEN-- RADIOSENSITIVITY EFFECTS
*THIOLS-- RADIOSENSITIVITY EFFECTS
560121* --Biomedical Sciences
Applied Studies--Radiation Effects--Radiation Effects on Cells--External Source
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
HAMSTERS
IRRADIATION
N48210* --Life Sciences--Radiation Effects on Cells-- External Source
X RADIATION