Radiation-Enhanced Survival of a Human Virus in Normal and Malignant Rat Cells
Journal Article
·
· Experimental Biology and Medicine
The repair phenomena of host-cell reactivation (HCR), uv reactivation (UVR) and X-ray reactivation (X-ray R) were studied in normal embryonic (OMRE) and malignant (RMT) rat cells of the same strain by examining the survival of uvirradiated herpes simplex virus (HV-1). Experiments indicated that HCR was present to the same extent in both OMRE and RMT cells as evidenced by similar e-1 values for both components of the virus survival curve as well as similar extrapolation numbers for the resistant component. UVR and X-ray R were demonstrated in RMT cells as indicated by enhanced survival of irradiated virus; however, both of these repair processes were absent in OMRE cells. The amount of UVR in RMT cells increased with virus uv dose and cell uv exposure. Finally, t was evident that HCR and radiation enhanced reactivation (UVR and X-ray R) may operate independently in these mammalian virus–host cell systems.
- Research Organization:
- Dept. of Health, Education, and Welfare, Rockville, MD
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-29-021116
- OSTI ID:
- 4351907
- Journal Information:
- Experimental Biology and Medicine, Journal Name: Experimental Biology and Medicine Journal Issue: 1 Vol. 145; ISSN 1535-3702
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
*ANIMAL CELLS-- BIOLOGICAL REPAIR
*VIRUSES-- BIOLOGICAL RADIATION EFFECTS
HERPES SIMPLEX
N48210* --Life Sciences--Radiation Effects on Cells-- External Source
N48310 --Life Sciences--Radiation Effects on Microorganisms--Basic Studies
NEOPLASMS
PHOTON BEAMS
RATS
SURVIVAL CURVES
ULTRAVIOLET RADIATION
X RADIATION
*VIRUSES-- BIOLOGICAL RADIATION EFFECTS
HERPES SIMPLEX
N48210* --Life Sciences--Radiation Effects on Cells-- External Source
N48310 --Life Sciences--Radiation Effects on Microorganisms--Basic Studies
NEOPLASMS
PHOTON BEAMS
RATS
SURVIVAL CURVES
ULTRAVIOLET RADIATION
X RADIATION