QUARTERLY PROGRESS REPORT NO. 25

Technical Report · Tue Oct 15 04:00:00 EDT 1957

OSTI ID:4344625

Data are presented on the survival time, weight loss, and montality of mice treated with 70 chemical compounds ethal dose whole-body x radiation. Marked protective effects were observed following the pre-irradiation intraperitoneal administration of dimethyldithiocarbnmic acid dimethylammonium salt, diethyldithiocarbamic acid diethylammonium salt, 2-aminoethanol, dithiol, monothiohydroquinone, and furfuryl mercaptan. Significant although lesser protective effects were seen following the administration of various doses of some of the other chemicals tested. Exposure of rats to fast neutron irradiation at a dose rate of 3.5 rep/hr caused n dosedependent increase in adenosine triphosphatase activity of the spleens and thymus glands throughout the range of 79 to 350 rcp, A similar relationship between dose and enzyme alteration was noted after gamma radiation under the same conditions of exposure in the dose range from 300 to 500 rep. Sublethal doses of fast neutron and Co/sup 60/ gamma irradiation were found to have effects qualitatively similar to x irr;idiation in depressing the endogenous respiration of spleen and thymus tissues of rats and these effects were found to be entirely reversible during a 14-day period. Data are included from studies on the effect of various steroids on the survival of x irradiated mice, studies on the antagonistic action of aminethylisothiuronium dichloride on the hyperglycemia induced by thiourea dcrivatives,and studies on the influence of fractionated exposures to low levels of gamma and fast neutron irradiation cn the mortality, survival time, and weight changes in mice. (For preceding period see NP-6398.) (C.H.)

• Research Organization: Chicago. Univ. Air Force Radiation Lab.
• NSA Number: NSA-12-002692
• OSTI ID: 4344625
• Report Number(s): NP-6491
• Country of Publication: United States
• Language: English

Related Subjects

ACIDS-- AMMONIUM COMPOUNDS-- BODY-- CARBAMATES-- CHEMICALS-- LETHAL DOSE-- LIFETIME-- LOSSES-- MICE-- ORGANIC SULFUR COMPOUNDS-- QUINONES-- RADIATION PROTECTION-- SALTS-- WEIGHT-- X RADIATION
ATP-ASE-- BIOCHEMISTRY-- BLOOD-- CHLORIDES-- COBALT 60-- ENZYMES-- FAST NEUTRONS-- GAMMA RADIATION-- LIFETIME-- ORGANIC SULFUR COMPOUNDS-- OXIDATION-- RADIATION DOSES-- RADIATION INJURIES-- RATS-- SPLEEN-- STEROIDS-- SUGARS-- THIOUREA-- THYMUS-- UREA- - WEIGHT
BIOLOGY AND MEDICINE