Chromosome breakage in human peripheral lymphocytes after radioactive iodine ($sup 125$I) treatment

Journal Article · Fri Mar 01 00:00:00 EDT 1974 · Radiat. Res., v. 57, no. 3, pp. 482-487

OSTI ID:4337882

Boyd, E; Ferguson-Smith, M A; McDougall, I R; Grieg, W R

Recent interest in the use of /sup 125/I (half-life 60 days) in prefcrence to /sup 131/I (half-life 8 days) in the treatment of thyrotoxicosis has prompted studies of possible undesirable extrathyroidal nadiation damage. The frequency of chromosome breakage in peripheral lymphocytes is one measure of this damage. A study in patients treated with /sup 125/I is described which shows as high a frequency of chromosome aberrations as is found after /sup 131/I therapy. The implications of this observation are discussed. (auth)

• Research Organization: Royal Hospital for Sick Children, Glasgow
• NSA Number: NSA-29-027121
• OSTI ID: 4337882
• Journal Information: Radiat. Res., v. 57, no. 3, pp. 482-487, Other Information: Orig. Receipt Date: 30-JUN-74
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

N48610* -Life Sciences-Radionuclide Effects (Internal Source)-Man
N48220 -Life Sciences-Radiation Effects on Cells-Internal Source
*CHROMOSOME BREAKAGE- RADIOINDUCTION
*IODINE 125- BIOLOGICAL RADIATION EFFECTS
*LYMPHOCYTES- CHROMOSOME BREAKAGE
*RADIOTHERAPY- SIDE EFFECTS
CHROMOSOMAL ABERRATIONS
MAN RADIOINDUCTION