ANTIBODY FORMATION IN X-IRRADIATED RATS PROTECTED WITH RAT OR RABBIT HEMATOPOIETIC CELLS
Journal Article
·
· Proc. Soc. Exptl. Biol. Med.
Rats given lethal doses of total-body x-irradiation were treated with liver cells obtained from rat and rabbit embryos. Two to 7 weeks after this treatment, groups of animals were stimulated with a mixture of Bovine Serum Albumin and Salmonella typhi vaccine intravenously. Rats were bled 1 week after antigen injections and titers were performod for detection of antityphoid and anti-BSA antibody. Rabbit-treated rats showed a positive titer to BSA and a delay in recovery of antibody-forming capacity to both antigens administered. Although rat-treated rats recovered their antibody-forming capicity earlier, they did not show any response to BSA. Possible implications of these phenomena are discussed. (auth)
- Research Organization:
- Argonne Cancer Research Hospital, Chicago; Univ. of Chicago
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-12-010333
- OSTI ID:
- 4335800
- Journal Information:
- Proc. Soc. Exptl. Biol. Med., Journal Name: Proc. Soc. Exptl. Biol. Med. Vol. Vol: 98
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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