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EFFECT OF TOTAL-BODY X RADIATION FROM NEAR-THRESHOLD TO TISSUE-LETHAL DOSES ON SMALL-BOWEL EPITHELIUM OF THE RAT. I. CHANGES IN MORPHOLOGY AND RATE OF CELL DIVISION IN RELATION TO TIME AND DOSE

Journal Article · · Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst.
OSTI ID:4334608
A study was made of changes in morphology and mitotic activity associated with changes in nucleic acid metabolism in small-intestinal epithelium of rats following whole-body x irradiation. Data are presented from quantitative measurements of changes in mitotic activity at various intervals after single doses varying from near-threshold to tissue-lethal. Results following local irradiation of an exteriorized loop of small intesting are included. The primary physical and chemical effects of irradiation on cells in interphase at the time of irradiation are discussed. It is concluded that acute cell destruction and prolongation of interphase of stem cells in the crypts of small-bowel epithelium are not mediated through any circulating toxic products or influenced by systemic effects resulting from irradiation. (C.H.)
Research Organization:
Naval Medical Research Inst.; National Cancer Inst., Bethesda, Md.
NSA Number:
NSA-12-012922
OSTI ID:
4334608
Journal Information:
Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst., Journal Name: Journal of the National Cancer Institute (U.S.) Changed to JNCI, J. Natl. Cancer Inst. Vol. Vol: 21; ISSN JNCIA
Country of Publication:
Country unknown/Code not available
Language:
English