Statistical analysis of longitudinal growth data on adolescents exposed in utero to the atomic bombs, Hiroshima and Nagasaki. Final report, January 1, 1971--February 29, 1972

Technical Report · Fri Mar 31 04:00:00 EST 1972

DOI:https://doi.org/10.2172/4331682· OSTI ID:4331682

Pasternack, B. S.

Since 1950 approximately 1600 exposed and control subjects who were in utero at the time of the atomic bombings (ATB) of Hiroshima and Nagasaki have been studied. The sample was drawn from the population of in utero children ATB who were either exposed or non-exposed (entering Hiroshima and Nagasaki between October 1945 and October 1955). Matching of subjects was carried out so that all available children exposed under 2,000 m were entered into the study. For each child exposed proximally an attempt was made to include a child exposed distally and one not-in-city ATB, matched by sex, month of birth, and economic status. Children at all stages of gestation were included. During the past year, a four parameter Gompertz-type model was used to characterize growth during adolescence for Japanese subjects who were in utero at the time of the atomic bombings of Japan in 1945. Based on maximum likelihood estimates of the four parameters, statistical analyses were performed to test for differences between sexes, cities, trimesters ATB, and exposure groups. The results obtained indicated that: males signiflcantly differed from females in all comparisons; differences among male exposure groups (indicating some impairment in adolescent growth) were greater than those for females; males and females in Nagasaki differed from those in Hiroshima, respectively; differences among trimester ATB groups were, almost without exception, non-significant; and age at onset of menarche and estimated age at the second point of inflection of the Gompertz growth curve were closely related. (auth)

• Research Organization: New York Univ., N.Y. (USA). Inst. of Environmental Medicine
• NSA Number: NSA-29-024475
• OSTI ID: 4331682
• Report Number(s): COO--3387-2
• Country of Publication: United States
• Language: English

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