Pulmonary carcinogenicity of relatively low doses of beta-particle radiation from inhaled {sup 144}CeO{sub 2} in rats
- Inhalation Toxicology Research Institute, Albuquerque, NM (United States); and others
This study was conducted to examine the carcinogenic effects of inhaled {beta}-particle-emitting radionuclides, particularly in lower dose regions in which there were substantial uncertainties associated with available information. A total of 2751 F344/N rats (1358 males and 1393 females) approximately 12 weeks of age at exposure were used. Of these, 1059 rats were exposed to aerosols of {sup 144}CeO{sub 2} to achieve mean desired initial lung burdens (ILBs) of 18 kBq (low level), 247 rats to achieve mean ILBs of 60 kBq (high level). Control rats (total of 1064) were exposed to aerosols of stable CeO{sub 2}. Based on the 95% confidence intervals of the median survival times and the cumulative survival of groups of female and male exposed rats relative to controls. The mean lifetime {beta}-particle doses to the lungs of the rats in the four groups were: low level, 3.6 {+-} 1.3 ({+-} SD) Gy; medium level, 6.1%; and high level, 19%. The estimated linear risk coefficient at the lower level was 39 {+-} 14 ({+-} SE) excess lung neoplasms per 10{sup 4} rat Gy; at the medium level the risk was 47 {+-} 12; and at the higher level the risk was 50 {+-} 9.0. The relationship of {beta}-particle dose to the lung and the crude incidence of lung neoplasms was described adequately by a linear function. We concluded that the risk of lung neoplasms in rats per unit of radiation dose did not increase with decreasing mean {beta}-particle dose to the lung over the range of 3.6 to 37 Gy. the weighted average of these three values was 47 {+-} 6.4 ({+-} SE) excess lung neoplasms to lower doses by experimentation will require much larger numbers of rats than used in this study. 39 refs., 5 figs., 8 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 433082
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Journal Issue: 5 Vol. 146; ISSN 0033-7587; ISSN RAREAE
- Country of Publication:
- United States
- Language:
- English
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