Use of dimethyl sulfoxide (DMSO) in radiation therapy

Journal Article · Mon Jan 01 04:00:00 EST 1973 · Radiobiol.-Radiother., v. 14, no. 5, pp. 471-479

OSTI ID:4328206

Glaser, F H

The present clinical examinstion deals with the possible use of DMSO in rsdiation therapy. DMSO was applied to 30 patients, 8 times in radiogenic subcutaneous fibroses, 13 times in contracted scars and keloids, 3 times in cases of induratio penis plastica, and 6 times as vehicle substsnce for tamor cell sensitization with vitamin A in the radiation therapy of skin metastases sfter mamma carcinoma. The results confirm the value of a DMSO treatment of subcutaneous fibroses following highly dosed percutaneous radiation therapy, especially in cases with a radiological ulcer. In keloids of scars a clear effect could be achieved without exceptions also in those csses showing only insufficient regression tendency to a preceded rsdiation therapy. The results of irradiation in cases with I.p.p., however, did not show any convincing improvement by a DMSO treatment. A new field of application is opened for the indiation therapy of recurrences and metastases in the area of the skin by sensitization of these cutaneous tumor infiltrates by vitamin A in connection with DMSO as vehicle substance so that a curative regression can be locally obtained by relatively low radiation doses. (auth)

• Research Organization: Martin Luther Univ., Halle, Ger.
• NSA Number: NSA-29-021171
• OSTI ID: 4328206
• Journal Information: Radiobiol.-Radiother., v. 14, no. 5, pp. 471-479, Journal Name: Radiobiol.-Radiother., v. 14, no. 5, pp. 471-479; ISSN RDBGA
• Country of Publication: Country unknown/Code not available
• Language: German

Related Subjects

*DMSO-- RADIOSENSITIVITY EFFECTS
*RADIOTHERAPY-- RADIOSENSITIVITY
*VITAMIN A-- RADIOSENSITIVITY EFFECTS
CARCINOMAS
FIBROSIS
N48510* --Life Sciences--Radiation Effects on Animals--Man
PATIENTS
TUMOR CELLS