Combined BCG and irradiation treatment of skin metastases originating from malignant melanoma

Journal Article · Wed Sep 15 04:00:00 EDT 1982 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19820915)50:6<1100::AID-CNCR2820500613>3.0.CO;2-6· OSTI ID:6579674

Plesnicar, S; Rudolf, Z

Treatment with BCG (Bacillus Calmette-Guerin) followed by irradiation was attempted to improve response to therapy by cutaneous metastases from malignant skin melanomas. Both agents were applied in low doses, known to cause minimal side effects. Nineteen patients, divided into three groups, entered the clinical trial. The first group consisted of five patients with numerous, small skin metastases. The nine patients of the second group presented a small number of relatively large metastases that usually appeared as a residual disease in the surgically treated area. Five patients with numerous, large metastases were included in the third group. The treatment sequence consisted of applying BCG intralesionally in doses from 4 x 10/sup 5/ to 1.17 x 10/sup 7/ viable units. After a free interval, the affected area was irradiated with doses from 1500-2500 ret. Patients with numerous small metastases and those with a small number of larger metastases, i.e., patients of the first and second group, showed a complete response and in these cases regression affected all the noninjected nodules and was also effective when regression could not have been achieved by BCG alone.

• Research Organization: Univ. of Ljubljana, Yugoslavia
• OSTI ID: 6579674
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 50:6; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL EFFECTS
BODY
DISEASES
FRACTIONATED IRRADIATION
INJECTION
INTAKE
IRRADIATION
LOW DOSE IRRADIATION
MEDICINE
MELANOMAS
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SKIN
THERAPY
VACCINES