Reliability of $sup 140$La-DPTA for the determination of glomerular filtration rate in man

Journal Article · Mon Jan 01 04:00:00 EST 1973 · J. Nucl. Biol. Med., v. 17, no. 4, pp. 158-161

OSTI ID:4327771

Bianchi, C; Coli, A; Palla, R; Lo Moro, A

The renal clearance of /sup 140/La-DTPA is very similar to the glomerular filtration rate (GFR) measured by /sup 131/I-hypaque; in contrast, endogenous creatinine clearance overestimates GFR. Furthermore, like /sup 131/I- hypaque and endogenous creatinine, /sup 140/La-DTPA does not seem to be reabsorbed by the tubule. In addition, the data support the conclusion that endogenous creatinine is also partially eliminated by tubular secretion in patients with good renal function. On the contrary, /sup 140/La-DTPA seems to be excreted by the kidney exclusively by means of glomerular filtration and therefore it may be used for the determination of GFR in man. (auth)

• Research Organization: Univ., Pisa, Italy
• NSA Number: NSA-29-021272
• OSTI ID: 4327771
• Journal Information: J. Nucl. Biol. Med., v. 17, no. 4, pp. 158-161, Journal Name: J. Nucl. Biol. Med., v. 17, no. 4, pp. 158-161; ISSN JNBMA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*GLOMERULI-- FILTRATION
*RENAL CLEARANCE-- TRACER TECHNIQUES
*TRACER TECHNIQUES-- LANTHANUM 140
DTPA
FLOW RATE
N48830* --Life Sciences--New Tracer Techniques--Other
PATIENTS