TURNOVER AND TISSUE DISTRIBUTION OF RADIO-RUTHENIUM OXIDE IN THE LUNGS OF MICE

Technical Report · Tue Oct 01 04:00:00 EDT 1957

OSTI ID:4325464

Willard, D H; Temple, L A; Bair, W J

Whole-body turnover and tissue distribution of ruthenium in mice were studied for 427 days after single intratracheal injections of Ru/sup 106/O/sub 2/. Because of a continuously changing rate of turnover several values for the biological haif life were calculated. Following the early period of high turnover rate the biological half life was 280 days when estimated by resolution of the turnover curve into a series of three exponentials. The retention of Ru/ sup 106/ was best represented by a power function and the average biological half life obtained by integration of the power function curvc over a period of 230 days was 170 days. Integration of the cxponential curve over the same period gave an average half life of ll0 days. After l64 days a portion of the animals were sacrificed to determine the tissue distribution of Ru/sup 106/. The total- body burden was l2% of the initial dose with 92% of the body burden in the lungs. Other tissues showing high concentrations of Ru/sup 106/ were the lymph nodes, spleen, kidney, and ovaries. (auth)

• Research Organization: General Electric Co. Hanford Atomic Products Operation, Richland, Wash.
• DOE Contract Number: W-31-109-ENG-52
• NSA Number: NSA-12-002722
• OSTI ID: 4325464
• Report Number(s): HW-52286
• Country of Publication: United States
• Language: English

Related Subjects

BIOLOGY
BIOLOGY AND MEDICINE
BODY
DISTRIBUTION
GONADS
HALF-LIFE
KIDNEYS
LUNGS
LYMPH SYSTEM
MATHEMATICS
MEASURED VALUES
METABOLISM
MICE
OVARIES
RUTHENIUM 106
RUTHENIUM OXIDES
SPLEEN
TISSUES