Effect of time between fractions on the response of tumors to irradiation

Journal Article · Fri Feb 01 04:00:00 EDT 1974 · Radiat. Res., v. 57, no. 2, pp. 342-348

DOI:https://doi.org/10.2307/3573840· OSTI ID:4310078

Howes, A E; Suit, H D

>Third-generation isotransplants of a C3H mouse mammary tumor were irradiated with fractionated doses of 250 kV x-rays. All the treatments consisted of five equal doses with the time between each fraction varyirg from 0 to 5 days. The tumors were irradiated under hypoxic, aerobic, or hyperbaroxic conditions, and response was expressed as the dose required to produce local control in 50% of each treatment group (TCD/sub 50/120 days/). The results have been interpreted in terms of a cell-survival theory and indicate that extensive repair, repopulation, and reoxygenation take place during the course of treatment. Further, by appropriate spacing of fractions, tumor response can be maximized, the optimal spacing being similar for both aerobic and hyperbaroxic treatments. (auth)

• Research Organization: M. D. Anderson Hospital, Houston, TX
• Sponsoring Organization: USDOE
• NSA Number: NSA-29-024502
• OSTI ID: 4310078
• Journal Information: Radiat. Res., v. 57, no. 2, pp. 342-348, Journal Name: Radiat. Res., v. 57, no. 2, pp. 342-348; ISSN RAREA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*BIOLOGICAL RADIATION EFFECTS-- FRACTIONATED IRRADIATION
*FRACTIONATED IRRADIATION-- BIOLOGICAL RADIATION EFFECTS
*NEOPLASMS-- BIOLOGICAL RADIATION EFFECTS
*OXYGEN-- RADIOSENSITIVITY EFFECTS
ANOXIA
DOSE-RESPONSE RELATIONSHIPS
MAMMARY GLANDS
MICE
N48520* --Life Sciences--Radiation Effects on Animals-- Vertebrates
PHOTON BEAMS
RESPONSE MODIFYING FACTORS
TIME DEPENDENCE
X RADIATION RADIOSENSITIVITY EFFECTS