Zirconium-labeled monoclonal antibodies and their distribution in tumor-bearing nude mice
Journal Article
·
· Journal of Nuclear Medicine
OSTI ID:430942
- Vrije Univ. Hospital, Amsterdam (Netherlands); and others
A method to label monoclonal antibodies (MAbs) with {sup 88}Zr and {sup 89}Zr has been developed and tested on the MAbs 323/A3 and E48. The bifunctional chelating agent desferal (Df) was linked through a thioether bond to the MAbs. Labeling was accomplished by addition of the premodified antibodies to isolated Zr. The retention of the in vivo behavior of the MAbs was determined by comparing the biodistribution of {sup 88}Zr-labeled MAbs with those of {sup 123}I and {sup 99m}Tc in mice bearing tumor xenografts. 45 refs., 7 figs., 1 tab.
- OSTI ID:
- 430942
- Journal Information:
- Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: 1 Vol. 38; ISSN 0161-5505; ISSN JNMEAQ
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparative biodistributions of yttrium- and indium-labeled monoclonal antibody B72. 3 in athymic mice bearing human colon carcinoma xenografts
(Investigations into the use of radiolabeled monoclonal antibodies for selective cell labeling in whole blood):
Pharmacokinetics of /sup 99m/Tc(Sn)- and /sup 131/I-labeled anti-carcinoembryonic antigen monoclonal antibody fragments in nude mice
Journal Article
·
Mon May 01 00:00:00 EDT 1989
· J. Nucl. Med.; (United States)
·
OSTI ID:5997434
(Investigations into the use of radiolabeled monoclonal antibodies for selective cell labeling in whole blood):
Technical Report
·
Wed Dec 31 23:00:00 EST 1986
·
OSTI ID:5242650
Pharmacokinetics of /sup 99m/Tc(Sn)- and /sup 131/I-labeled anti-carcinoembryonic antigen monoclonal antibody fragments in nude mice
Journal Article
·
Sat Mar 14 23:00:00 EST 1987
· Cancer Res.; (United States)
·
OSTI ID:6863071