Computer scintigraphy for detecting liver tumor using a scintillation camera and $sup 67$Ga-citrate (in Japanese)
Nineteen patients bearing focal defects on the liver scans with radiocolloid were studied with /sup 67/Ga-citrate. Images of the liver were obtained 48 to 72 hrs after injection of 1 to 2 mCi of /sup 67/Gacitrate intravenously. A scintillation camera (Pho/Gamma III) was used, and all images were recorded on Polaroid films. In addition to the conventional Polaroid photographs, the data were also fed into a computer sysiem and stored in the memory cores. Definite tumor accumulation of the /sup 67/Ga-citrate was noted in 14 of 15 patients with malignant tumors---4 of 5 with hepatocellular carcinomas, 3 of 9 with metastatic liver tumors. The tracers were poorly accumulated by a hepatocellular carcinoma, a cholangiohepatic carcinoma, and five metastatic liver tumors. The gallium study was found to be helpful in the differential diagnosis of focal liver abnormalities detected by /sup 99m/Tc-sulfur colloid scans. A focal liver abnormality that accumulated more gallium than surrounding normal tissue was more likely to be malignant tumor than benign condition such as cirrhosis. The combination of /sup 67/Gacitrate and /sup 99m/Tc-sulfur colloid was found to be helpful to distinguish the patients with hepatic malignancies to those with cirrhotic scarring. After the /sup 67/Ga siudy was performed with leaving the patient in the same position under the detector, we gave 1 mCi of / sup 99m/Tc-suliur colloid intravenously and again obtain a san image of the liver. All data were stored in the tape recorder to provide it for computer scintigraphy and for subtraction scintigram. Gallium-67 citrate distributes also within the normal liver tissue. This made it difficult to deliniate the tumor image of the liver. The computer subtraction scintigraphy with the use of /sup 67/Ga-citrate and /sup 198/Au-colloid or /sup 99m/Tc-sulfur colloid allow to overcome the disadvantage of /sup 67/Ga-citrate. (auth)
- Research Organization:
- Okayama Univ., Japan
- NSA Number:
- NSA-29-027177
- OSTI ID:
- 4308729
- Journal Information:
- Kaku Igaku, v. 10, no. 5, pp. 467-477, Other Information: Orig. Receipt Date: 30-JUN-74; Bib. Info. Source: JA (JA)
- Country of Publication:
- Japan
- Language:
- Japanese
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