NEW RADIODIAGNOSTIC TECHNIQUES FOR INVESTIGATING PARENCHYMAL AND OBSTRUCTIVE LIVER AND KIDNEY DISEASE. Pathophysiological Studies in Animals and Clinical Applications

Technical Report · Fri Oct 31 04:00:00 EST 1958

OSTI ID:4308563

Taplin, G V; Meredith, Jr, O M; Kade, H; Winter, C C; Johnson, D

ABS>Recent advances in the development and clinical evaluation of external tracer techniquues for measuring multiple functions of the liver and kidneys with I/sup 131/ labeled Rose Bengal I/sup 131/ and Diodrast are described. The Rose Bengal I/sup 131/ blood clearance-liver uptake tracer test provides reliable indices of polygonal cell function and liver vascular capacity. The sensitivity of the tracer test is increased by the simultaneous injection of bromsulphalein in stress doses of 3-5 mg/kg, Normal tracer and stress test findings indicate the absence of significant liver pathology. A dual Rose Bengal I/sup 131/ Hepatogram, a multipurpose tracer procedure, is useful in the differential diagnosis of medical versus surgical jaundice. When-the Hepatogram is used repeatedly in patients with hepatobiliary diseases results correlate well with the clinical findings and indicate changes in the underlyingpathophysiologicai disturbances more quickly and accurately than do indirect biochemical liver tests. The for measuring tubular ccll function is no greater than . simple nontraumatic method for measuring multiple functions of each kidney separately make it a valuable - procedure in the practice of urology. Futhermore, the renogram has been demonstrated to by a reliable rapid screening test for hypertensive patients suspected of having unilateral renal lesions. It provides a simple diagnostic tool which is needed to extend the investigation of renal hypertension into the field of pediatrics. Most hypertensive patients having normal renogram findings may be spared the discomfort, time, and expense of extensive urological investigations, which are otherwise considered essential. (auth)

• Research Organization: California. Univ., Los Angeles. Atomic Energy Project; California. Univ., Los Angeles. School of Medicine; Veterans Administration Center, Los Angeles; Los Angeles County Harbor General Hospital, Torrance, Calif.
• NSA Number: NSA-12-014584
• OSTI ID: 4308563
• Report Number(s): A/CONF.15/P/870
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE-- BIOCHEMISTRY-- BLOOD-- BLOOD CIRCULATION-- CYTOLOGY-- DIAGNOSIS-- DIODRAST-- DISEASES-- DYES-- HYPERTENSION-- IODINE 131-- KIDNEYS-- LABELLED COMPOUNDS-- LIVER-- MAN-- MEASURED VALUES-- MEDICINE-- METABOLISM-- PRESSURE-- RADIOGRAPHY-- SENSITIVITY-- USES
BIOLOGY AND MEDICINE
BLOOD-- BLOOD VESSELS-- CONFERENCE-- CYTOLOGY-- DIAGNOSIS-- DIODRAST-- DISEASES-- DISTRIBUTION-- DYES-- IODINE 131-- JAUNDICE-- KIDNEYS-- LABELLED COMPOUNDS-- LIVER-- MEASURED VALUES-- METABOLISM-- PHYSIOLOGY-- QUANTITY RATIO-- RADIOGRAPHY-- ROSE BENGAL-- SENSITIVITY-- SURGERY-- TESTING-- TISSUES-- TRACER TECHNIQUES-- VARIATIONS