Rose bengal and iodopyracet as radio-diagnostic agents in liver and kidney diseases

Journal Article · Wed Jul 01 04:00:00 EDT 1959 · Annals of the New York Academy of Sciences

DOI:https://doi.org/10.1111/j.1749-6632.1959.tb56071.x· OSTI ID:4234641

Taplin, G. V.; Meredith, O. M.; Winter, C. C.; Johnson, D.

The rose bengal hepatogram is now established as a highly sensitive liver function test that also supplies diagostic information on vascular abnormalities of the liver and on the degree of biliary tract obstruction. No other single procedure gives as much useful information for the differential diagnosis and management of patients with diseases of the liver and biliary tract. The rose bengal-BSP blood clearance stress test is capable of detecting minimal liver damage in rabbits and asymptomatic liver disease in man. However, further investigation is needed for final assessment of its maximum sensitivity. New tracer techniques using colloidal gold/sup 198/ and rose bengal have been developed in animal studies for further evaluation of liver vascular disorders; both procedures are clinically applicable. The Diodrast renogram is becoming recognized as a simple, rapid, nontraumatic office procedure for estimating individual kidney functions. It is especially valuable as a screening test for hypertensive patients suspected of having disease of one kidney. Most hypetensives with normal renograms may be spared the discomfort, time, and expense of hospitalization and complicated urological diagnostic procedures. Recent modifications in the instrumentation and the use of Miokon in place of Diodrast have increased the reliability of the renogram while simplifying its performance. These tracer tests are unique in providing data on multiple functions simultaneously with complete freedom from drug reactions; radiation exposure is many times less than from X-ray examinations of these organs.

• Research Organization: Univ. of California, Los Angeles; Veterans Administration Center, Los Angeles; and Los Angeles County Harbor General Hospital, Torrance, Calif.
• Sponsoring Organization: USDOE
• NSA Number: NSA-13-021848
• OSTI ID: 4234641
• Journal Information: Annals of the New York Academy of Sciences, Journal Name: Annals of the New York Academy of Sciences Journal Issue: 3 Vol. 78; ISSN 0077-8923
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BLOOD VESSELS
DIAGNOSIS
DIODRAST
DISEASES
DRUGS
DYES
GOLD 198
IODINE
KIDNEYS
LIVER
MAN
RABBITS
RADIOGRAPHY
ROSE BENGAL
TESTING
TRACER TECHNIQUES
X RADIATION