HISTOCHEMICAL STUDY OF THE PHAGOCYTIC PROCESSES IN THE RABBIT APPENDICES IN X-RAY IRRADIATION

Journal Article · Tue Jul 01 04:00:00 EDT 1958 · Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR

OSTI ID:4301550

Fridenstein, A Ya

The study of the dynamics of phagocytic processes was carried out in the appendicular wall of normal and irradiated rabbits. Histochemical methods of detection of polysaccharides were used. It appeared that a considerable amount of microbes which constitute the natural flora of the large intestine penetrate through the epithelium of appendix of normal adult rabbits. These microbes are seized by reticular cells of lymphoid follicles and are digested in the process of multiphasic phagocytosis. As a result of this, a large number of substances formed in decomposition of microbes are deposited in the centers of multiplication of the follicles, in the wall of the appendix the greater part of these substances give a positive reaction to polysaccharides. The total x-ray dose of 600 to 800 r causes disturbance of the phagocytic apparatus referred to above: the process of phagocytosis by macrophages becomes incomplete and the process of deposition of the substances formed in destruction of microbes becomes disturbed. The apparatus of phagocytic protection which was revealed in the intestinal wall points to the role of macrophagic reaction in the natural immnuity. Evidently, the development of radiation bacteremia is connected with disturbance of this reaction in irradiation. (tr-auth)

• Research Organization: Gamalei Inst. of Epidemiology and Microbiology, Academy of Medical Sciences, USSR
• NSA Number: NSA-13-000034
• OSTI ID: 4301550
• Journal Information: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR, Journal Name: Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR Vol. Vol: 3, No. 4; ISSN MERAA
• Country of Publication: Country unknown/Code not available
• Language: Russian

Related Subjects

AGE
ANIMAL CELLS
APPENDIX
BIOCHEMISTRY
BIOLOGY AND MEDICINE
CARBOHYDRATES
IMMUNITY
INTESTINE
IRRADIATION
LYMPH SYSTEM
MACROPHAGES
MICROORGANISMS
PHAGOCYTOSIS
POLYMERS
QUANTITATIVE ANALYSIS
RABBITS
RADIATION DOSES
RADIATION EFFECTS
X RADIATION