RADIATION DAMAGE IN THE DEVELOPING GERM CELLS OF DROSOPHILA VIRILIS FROM FAST NEUTRON TREATMENT
Journal Article
·
· Genetics (U.S.)
OSTI ID:4298855
The radiation damage produced by the densely ionizing rsdintions from fission neutrons was tested by studies of various stages of post- and premeiotic germ cells of Drosophila virilis. Young males were treated with doses of 600, 1200, and 2400 x 10/sup 8/n/sup f/cm/sup 2 and the various types of cells sampled by successive remating periods. The induction of translocations and dominant lethals in the various stages of spermatogenesis was tested. Translocation and dominant lethal damage produced from neutron treatment in the immature germ cells increased proportionally with an increase in dose. The damage obtained for each type of cell in the spermatogenic cycle resulted in a curve which would be expected when multlple chromosome breakage is produced from a single proton hit. The radintion damage increased linearly with dose in the various types of cells although the relative seQitivity of the various stages was not the same. Postmeiotic germ cells (B-D) varied in sensitivity to chromosome breakage with the sensitivity peak ocurring in the spermatozoa sampled 13-15 days after treatment (Period D). A neutron dose of 1.5 to 2 times greater is required to produce the same amount of radiation damage in the more mature type of cells (B) as with the D types. Cells treated in meiotic and premeiotic stages contained fewer translocations and lower percentages of dominant lethals than postmeiotic cells. The reduction in the number of spermatozoa in the treated males in mating period G indicates that some types of spermatogonial germ cells degenerate as a result of neutron irradiation. The relative biological efficiency of fission neutrons and 200 kv x rays differ in mature sperm, spermatids and meiotic cells. Fission neutrons are at least six times more effectlve than x ray in mature sperm; in spermatids, the difference is only two to three times larger for neutrons. In meiotic cells fission neutrons are only 1.6 times more efficient. (anth)
- Research Organization:
- Univ. of Texas, Austin; Brookhaven National Lab., Upton, N.Y.
- NSA Number:
- NSA-13-001911
- OSTI ID:
- 4298855
- Journal Information:
- Genetics (U.S.), Journal Name: Genetics (U.S.) Vol. Vol: 43; ISSN GENTA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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