Ways of Use of Ionizing Radiation in the Manufacture of Bacterial Preparations; PUTI ISPOL'ZOVANIYA IONIZIRUYUSHCHEI RADIATSII V PROIZVODSTVE BAKTERIINYKH PREPARATOV

Technical Report · Sat Oct 31 00:00:00 EST 1959

OSTI ID:4292091

Troitskii, V L; Tumanyan, M A

Experiments are reported which give encouraging results for applications of ionizing radiations in the sterilization of vaccines, antitoxins, and serums for use in medical prophylaxis and treatment. A cobalt-60 gamma source was used. A dose of 1.5 Mr had a sterilizing effect, killing not only vegetative bacteria but sporeformers as well. Irradiation with sterilizing doses did not reduce the nutrient properties of meat media used for growth of bacteria of the intestinal group. The formation of diphtheria toxin proceeded on irradiated media the same as on nonirradiated. Irradiation did not reduce the antigenic or immunological properties of typhoid vaccines or diphtheria and tetanus antitoxins. Serum products deteriorated after exposure to sterilizing doses but showed good tolerances to doses which killed vegetative forms of bacteria. It was concluded that ionizing radiation will prove practical for the preparation of many pharmaceutical products, the cold sterilization of nutrient broth, and the cold sterilization of the wastes from the manufacture of bacterial preparations. (C.H.)

• Research Organization: U.S.S.R.
• NSA Number: NSA-13-006269
• OSTI ID: 4292091
• Report Number(s): A/CONF.15/P/2071
• Resource Relation: Other Information: Orig. Receipt Date: 31-DEC-59
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
ANTIGENS
ANTITOXINS
BACTERIA
COBALT 60
DIPHTHERIA
DRUGS
GAMMA RADIATION
GAMMA SOURCES
IMMUNITY
INFECTIONS
INTESTINE
LOW TEMPERATURE
MEAT
MICROORGANISMS
PREPARATION
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY
RESIDUES
STERILIZATION
TETANUS
TOXICITY
TYPHOID
USES
VACCINES
X RADIATION