Comparative Study of the Effects of X Rays and of $sup 32$P on the Degradation and Synthesis of the Nucleic Acids of the Bone Marrow and the Spleen in Rats; ETUDE COMPAREE DES EFFETS DES RAYONS X ET DU $sup 32$P SUR LA DEGRADATION ET LA SYNTHESE DES ACIDES NUCLEIQUES DE LA MOELLE OSSEUSE ET DE LA RATE, CHEZ LE RAT
The effect of various doses of x radiation and P/sup 32/ injections on the ribonucleic and desoxyribonucleic acids of the bone marrow and spleen was studied. The evolution of the absolute quantity was studied. The degradation for RNA for doses of 325, 500, 700, 1000, and 1500 r was 42, 55, 60, 65, and 72%, respectively, and 66, 70, 80, 85, and 91% for the same irradiation of DNA. Regeneration after sublethal doses occurs after the fourth day. Administration of 200, 300 or 400 mu c of P/sup 32/ produces on the fourth day in the marrow an average degradation of 33, 51, and 62% for RNA and 46, 44, and 72% for DNA. The effect of 200 mu c is therefore of the same order as 325 r of whole-body irradiation, and that of 400 mu c is close to the sublethal dose of 700 r. In the case of the spleen, the effects of 400 mu c are in the vicinity of those of 500 r. (J.S.R.)
- Research Organization:
- Univ. of Strasbourg
- NSA Number:
- NSA-13-006163
- OSTI ID:
- 4289017
- Report Number(s):
- A/CONF.15/P/1236
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-59
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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