EXPERIENCE OF TREATMENT AND PROPHYLAXIS OF RADIATION DISEASE WITH LEUCOCYTE AND THROMBOCYTE MASSES

Technical Report · Sat Oct 31 04:00:00 EST 1959

OSTI ID:4287648

Bagdasarov, A A; Vinograd-Finkel, F K

Beneficial effects are reported following the administration of mass transfusions of leukocytes or thrombocytes to dogs following exposure to LD/sub 95/ doses of whole-body x radiation. Transfused thrombocytes labeled with chromium-51 were observed in the blood of recipients 7 days after transfusion. Good results are reported in patients suffering from radiation sickness induced by radiation therapy treated with repeated mass transfusions of leukocytes prepared from non-citrated blood and preserved with the aid of ion-exchange resins. This method of preservation was found to result in a prolonged viability of leukocytes. The mass leukocytes also contained some thrombocytes. One dose of mass leukocytes prepared from 450 ml of blood contains an average of 2 billion leukocytes. From 3 to 8 transfusions were necessary to attain positive results. In cases of significant thrombocyte decrease additional transfusions of mass thrombocytes were given. The administration of mass leukocyte transfusions at the beginning of radiation therapy prevented or reduced the development of leukopenia and other disorders of hematopoiesis. (C.H.)

• Research Organization: U.S.S.R.
• NSA Number: NSA-13-006298
• OSTI ID: 4287648
• Report Number(s): A/CONF.15/P/2238
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY
CHROMIUM 51
DOGS
EFFICIENCY
ION EXCHANGE
IRRADIATION
LEUCOCYTES
MAN
PLATELETS
RADIATION DOSES
RADIATION INJURIES
RADIATION SICKNESS
RADIOTHERAPY
RESINS
TRACER TECHNIQUES
TRANSFUSIONS
TRANSPLANTS
X RADIATION