PRIMARY ANTIBODY RESPONSE TO A CLOSELY RELATED HETEROLOGOUS ANTIGEN AFTER VARYING DOSES OF X-RADIATION, AND ITS SIGNIFICANCE TO RELATED BIOLOGIC PHENOMENA

Journal Article · Mon Dec 01 04:00:00 EST 1958 · Journal of Immunology (U.S.)

OSTI ID:4280989

Makinodan, T; Gengozian, N

ABS>The intraperitoneal route of antigen injection in normal adult mice was closely comparable to the intravenous route in terms of induction period, rate of appearance of antibodies and mean peak titer, and was superior only in terms of the mean total titer. Increase dn the antigen concentration from 1 to 10% in 1 ml of RBC did not significantly raise the agglutinin titers of 500-r mice on days 6 to 50, but did raise the mean total titer slightly. A curvilinear relation for the radiation dose and antibody response was obtained in terms of the induction period, rate of appearance of antibodies, mean peak titer, and mean total titer. The significance of these findings is discussed. (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• NSA Number: NSA-13-007406
• OSTI ID: 4280989
• Journal Information: Journal of Immunology (U.S.), Journal Name: Journal of Immunology (U.S.) Vol. Vol: 81; ISSN JOIMA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANTIBODIES
ANTIGENS
BIOLOGY AND MEDICINE
DIAGRAMS
ERYTHROCYTES
IMMUNITY
MICE
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RADIOBIOLOGY
X RADIATION