A STUDY OF THE EFFECTS OF TOTAL AND PARTIAL BODY RADIATION ON IRON METABOLISM AND HEMATOPOIESIS. Progress Report for Period September 1, 1957 to February 28, 1958
Procedures are described which were used in the calibration of a 2-Mev Van de Graaff generator and in radiation dosage determinations. Data are tabulated from tracer studies using iron-59 labeled serum iron to determine the effect of radiation on erythropoiesis in human patients with cancer or various hematologic disorders. The intensive irradiation of blood in extra-corporeal, circulation induced an initial depression of white blood cell count followed by an elevation which persisted for several weeks. When plasma from the treated dogs was administered intravenously to normal dogs, an initial depression was followed by a sustained rise in values for hemoglobin, red count, and white count. Autotransfusion with 500 cc of irradiated whole blood resulted in a temporary rise in values for hemoglobin, red cell, and white cell count in a cancer patient with microcytic anemia. An investigation was started of the lethal radiation dose for dogs. Observations were made on patients receiving whole-body irradiation in an effort to establish a relationship between individual radiosensitivity and the presence of concomitant disease. (C.H.)
- Research Organization:
- Baylor Univ., Houston, Tex. Coll. of Medicine and Jefferson Davis Hospital, Houston, Tex.
- NSA Number:
- NSA-13-005215
- OSTI ID:
- 4278904
- Report Number(s):
- AD-161955
- Country of Publication:
- United States
- Language:
- English
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