INTERRELATIONSHIP BETWEEN SERUM CALCIUM LEVELS: CALCIUM$sup 45$ AND STRONTIUM$sup 85$ METABOLISM IN MAN
The effect of acute elevntion or depression of serum calcium upon the intestinal absorption and upon the metabolism of the absorbed calcium and strontium was investigated in two patients. The serum calcium was raised or lowered by a 6-hour infusion of calcium gluconnie or sodium ethylenediaminetetraacetate. A tracer dose of Ca/sup 45/ and S/sup 85/ was administered orally at that time. Acute changes of the serum calcium levels had no significantin fluence on the absorption of either calcium or strontium; the absorption of Ca/sup 45/ exceeded that of Sr/sup 85/ under all conditions studied. The urinary excretion of Sr/sup 85/ exceeded considerably that of Ca/sup 45/ in the normocalcemic state. During hypercalcemia the excretion of both tracers increased; ethylenediaminetetraacetic acid caused a marked increment of Ca/sup 45/ and a marked decrease of Sr/sup 85/ excretion. The endogenous fecal excretion of Sr/sup 85/ was slightly higher than that of Ca/sup 45/ in all studies. (auth)
- Research Organization:
- U.S. Public Health Service; U.S. Atomic Energy Commission, New York
- NSA Number:
- NSA-13-003537
- OSTI ID:
- 4267063
- Journal Information:
- Journal of Laboratory and Clinical Medicine (U.S.), Journal Name: Journal of Laboratory and Clinical Medicine (U.S.) Vol. Vol: 52; ISSN JLCMA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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