A gene map of the human genome
- National Library of Medicine, Bethesda, MD (United States)
- Stanford Univ. School of Medicine, CA (United States); and others
The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeast artificial chromosome library. More than 16,000 human genes have been mapped relative to a framework map that contains about 1000 polymorphic genetic markers. The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease. 45 refs., 4 figs., 3 tabs.
- OSTI ID:
- 426089
- Journal Information:
- Science, Journal Name: Science Journal Issue: 5287 Vol. 274; ISSN SCIEAS; ISSN 0036-8075
- Country of Publication:
- United States
- Language:
- English
Similar Records
An overview of the human genome project
Current trends in mapping human genes
DOE to map expressed genes
Conference
·
Fri Dec 31 23:00:00 EST 1993
·
OSTI ID:10131844
Current trends in mapping human genes
Journal Article
·
Mon Dec 31 23:00:00 EST 1990
· FASEB Journal (Federation of American Societies for Experimental Biology); (USA)
·
OSTI ID:5583381
DOE to map expressed genes
Journal Article
·
Thu Nov 15 23:00:00 EST 1990
· Science (Washington, D.C.); (USA)
·
OSTI ID:5922069