STUDY OF LONG-TERM PATHOLOGIC EFFECTS OF RADIOACTIVE ISOTOPES OF CALCIUM AND STRONTIUM IN BONE AND SOFT TISSUES, ESPECIALLY WITH REFERENCE TO BONE TUMOR PRODUCTION. Final Technical Report for May 16, 1958-August 31, 1959

Technical Report · Mon Oct 31 04:00:00 EST 1960

OSTI ID:4239403

Kuzma, J F; Zander-Principati, G E

Findings are summarized from a nine-year study on the pathologic effects of radioactive strontium and calcium in bone and soft tissues of mice, rats, and dogs. Data are included on the incidence of bone tumors following injection of sirontium-89 and calcium-45, the effectiveness of zirconium citrate and other chemicals in prolonging the lateni period of stroniium-89 induced bone cancer; the effects of surgical removal of strontium-89 burdened bone spongiosa on incidence of bone tumors; the effect of cold environment on the development of bone tumors following injection of cancerogenic dose of strontium-89: the long- term pathologic effects of strontium-89 -90 in pregnant mice, their offspring, and later generations; the effect of chronic lead intoxication on bone cancer production by radioactive calcium or strontium; the effect of beta- aminopropionitrile fumarate on strontium-89 production of bone tumors; the effect of a low phosphorus diet on the production of bone tumors by strontium-89; the development of squamous cell carcinoma at the site of injection of strontium-89; and the retention of cancerogenic doses of strontium-89 -90 by various parts of the skeleton. Counting techniques are described. (C.H.)

• Research Organization: Marquette Univ., Milwaukee. School of Medicine
• NSA Number: NSA-14-001349
• OSTI ID: 4239403
• Report Number(s): AECU-4409
• Country of Publication: United States
• Language: English

Related Subjects

AMINES
BIOLOGY AND MEDICINE
BONES
CALCIUM 45
CARCINOGENESIS
CHEMICALS
CITRIC ACID
CYANIDES
DIET
DOGS
FUMARIC ACID
METABOLISM
MICE
NITRILES
ORGANIC ACIDS
PHOSPHORUS
PREGNANCY
PROPIONIC ACID
QUANTITY RATIO
RADIATION INJURIES
RATS
REPRODUCTION
STRONTIUM 89
SURGERY
TISSUES
TOXICITY
ZIRCONIUM COMPLEXES
ZIRCONIUM COMPOUNDS