STUDIES ON THE METABOLISM OF NUCLEIC ACID IN CARCINOMA CERVIX UTERI, WITH PARTICULAR REFERENCE TO CHANGES DUE TO IRRADIATION WITH Co$sup 6$$sup 0$

Journal Article · Sun Mar 01 04:00:00 EST 1959 · Acta Med. et Biol. (Niigata)

OSTI ID:4234719

Taira, K

In biochemical studies on the cellular constituents of tumor tissues in 20 cases of carcinoma cervix uteri irradiated with Co/sup 60/ and in 15 controls not irradiated, the quantitutive determinations for various phosphoric fractions, i.e., acid-soluble P, lipid-P, RNA-P, and DNA-P, showed the DNA-P diminish with statistical significance in the irradiated groups. The other fractions remained unchanged by irradiation. Study of the influence of irradiation on the P/sup 32/ incorporation into the different fractions in terms of relative specific activity (RSA), found the P/sup 32/ incorporation into only the DNA fractions remarkably inhibited; and the incorporation of P/sup 32/ into RNA was also diminished to some extent but not to such an extent as would show a statistically significant difference from the findings in the controls. Similar experiments using different doses of Co/sup 60/ irradiation led to this finding: the quantitutively determined values and RSA exhibited marked decline in DNA-P with increasing doses of the irradiation, and tended to decrease in RNA following irradiation at high doses. As for the relationship between the histological grades of carcinoma cervix uteri and cellular constituents, the higher the histological grade the more was the amount of DNA-P, with marked rise in the P/sup 32/ incorporation into DNA. These appeared capable of being used as an index for the histological grade of malignancy. While RNA-P was practically not affected by rise in the histological grade, the P/sup 32/ incorporation into RNA rose to some extent with rise in the histological grade. The irradiation of the histologically classified groups showed that the higher the histological grade of malignancy in the group the lower were the amount of DNA-P and RSA. (auth)

• Research Organization: Niigata Univ., Japan
• NSA Number: NSA-13-021840
• OSTI ID: 4234719
• Journal Information: Acta Med. et Biol. (Niigata), Journal Name: Acta Med. et Biol. (Niigata) Vol. Vol: 6
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACIDS
BIOCHEMISTRY
BIOLOGY AND MEDICINE
CANCER
COBALT 60
CONTROL
DNA
LIPIDS
MAN
METABOLISM
NUCLEIC ACIDS
PHOSPHORUS 32
PHOSPHORUS COMPOUNDS
RADIATION DOSES
RADIATION EFFECTS
RADIOTHERAPY
RIBONUCLEIC ACID
SEX
TISSUES
TRACER TECHNIQUES
UTERUS