PHARMACOLOGICAL STUDIES ON IRRADIATED ANIMALS. VII. PROTECTION OF GUINEA PIGS AGAINST RADIATION-INDUCED MORTALITY BY CELL-FREE MOUSE SPLEEN EXTRACT STORED FOR ONE YEAR

Technical Report · Sun Mar 01 00:00:00 EST 1959

OSTI ID:4222603

Ellinger, F

Previous observations concenaing a protective effect of heterologous cell-free total spleen extracts, i.e., injection of mouse spleen extracts into guinea pigs after their exposure to a lethal dose of ionizing radiation, are confirmed. It is demonstrated furthermore that the active principle remains stable within these crude extracts fcr a period of one year if the lyophilized extract is stored in a refrigerator. The significance of these observations for isolation and identification of the active principle is discussed, as well as the possibility to use crude spleen extracts for the postirradiation treatment of the acute radiation syndrome. (auth)

• Research Organization: Naval Medical Research Inst., Bethesda, Md.
• NSA Number: NSA-13-020789
• OSTI ID: 4222603
• Report Number(s): AFSWP-1087; NM 62 04 00.03.02
• Resource Relation: Other Information: Orig. Receipt Date: 31-DEC-59
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
EFFICIENCY
GUINEA PIGS
IMMUNITY
IRRADIATION
LETHAL DOSE
LOW TEMPERATURE
LYOPHILIZATION
MEDICINE
MICE
PREPARATION
PRESERVATION
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
SOLUTIONS
SOLVENT EXTRACTION
SPLEEN
STORAGE
TEMPERATURE
TISSUES