FURTHER INVESTIGATION OF THE EFFECT OF ROENTGEN IRRADIATION UPON THE DEVELOPMENT OF THE HEAD OF THE YOUNG AXOLOTL
The anterior portion or complete head of 120 animals 25 to 32 days after hatching was irradiated mostly with 3,000 r (in one group of 15 with 6,000 r). Definite suppression of growth of the irradiated portion of the head was observed 80 to 110 days after treatment. Especially great was the suppression of the rostral end of the head and lower jaw. The study of reconstructions from sagittal and frontal sections showed the following: the teeth disappeared completely; the growth of olfactory chambers was suppressed greatly, but the olfactory chambers never disappeared completely; the growth of the lower jaw was suppressed and its anterior portion had disappeared; as a result of the reduction of the anterior portion of the lower jaw, the visceral arches shifted in rostral direction; the development of the eyes was suppressed. The tissues and organs of the head of the axolotl are placed in order of decreasing radiosensitivity into the following five groups: (1) The teeth and lymph nodes, which were the most radiosensitive; (2) the olfactory epithelium and the lens; (3) the epithleium of the cornea, the rods and cones layer of the retina, and the gills; (4) other layers of the retina; and (5) the pigment cells of choroid and other tissues of the head, which were comparatively resistant and did not show any clear signs of damage. Specialized but not completely differentiated tissues can be destroyed by roentgen irradiation, after which they are never restored, being replaced by typical skin epithelium with Leydig's cells. This was observed in oral epithelium that forms enamel organs of the teeth, olfactory epithelium of the nasal chambers, and epithelium of the cornea. (auth)
- Research Organization:
- Roswell Park Memorial Inst., Buffalo
- NSA Number:
- NSA-13-020806
- OSTI ID:
- 4222415
- Journal Information:
- Am. J. Roentgenol., Radium Therapy Nuclear Med., Journal Name: Am. J. Roentgenol., Radium Therapy Nuclear Med. Vol. Vol: 82
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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