EFFECT OF HYDROGEN PEROXIDE ON EHRLICH ASCITES TUMOR CELLS DURING $gamma$- IRRADIATION

Journal Article · Sat Aug 01 04:00:00 EDT 1959 · Med. J. Osaka Univ.

OSTI ID:4221205

Takayama, H; Hirano, K; Nishioka, K; Sunada, T

Since it is known that oxygen deficiency protects against gamma - irradiation, it was assumed that an excess of oxygen or of some similar substance might promote the biological effects of gamma -irradiation. H/sub 2/O/sub 2/ was tested as that assumed promotor. A mixture of Ehrlich ascites tumor cells and H/sub 2/O/sub 2/ (which was so dilute as to cause no death of cells) was irradiated in vitro with gamma -rays for a single dose lower than the dose necessary in prevent the irradiated cells from producing ascites tumors. The irradiated mixture was injected intraperitoneally into mice. Although control animals all died of ascites tumors, the experimental group into which H/sub 2/O/ sub 2/ treated irradiated cells were injected did not show ascites tumor death after two months observation. These effects were not found when benzperoxide was substituted for H/sub 2/O/sub 2/. Ferric chloride was used in an attempt to icrease the production of the HO/sub 2/ radical but had no effect. (auth)

• Research Organization: Osaka Univ.
• NSA Number: NSA-14-002328
• OSTI ID: 4221205
• Journal Information: Med. J. Osaka Univ., Journal Name: Med. J. Osaka Univ. Vol. Vol: 10
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BENZENE
BIOLOGY AND MEDICINE
EHRLICH ASCITES
GAMMA RADIATION
HYDROGEN PEROXIDES
IRON CHLORIDES
MICE
OXYGEN
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
TUMORS