Hypoadrenocorticism in beagles exposed to aerosols of plutonium-238 dioxide by inhalation
- Pacific Northwest National Lab., Richland, WA (United States); and others
Hypoadrenocorticism, known as Addison`s disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of {sup 238}PuO{sub 2}. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoadiographs showed only slight {alpha}-particle activity. Although the pathogenesis of adrenal cortical atrophy in these dogs is unclear, there is evidence to suggest an automimmune disorder linked to damage resulting from {alpha}-particle irradiation to the lymphatic system.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 420454
- Journal Information:
- Radiation Research, Vol. 146, Issue 6; Other Information: PBD: Dec 1996
- Country of Publication:
- United States
- Language:
- English
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