BIOLOGY AND MEDICINE SEMIANNUAL REPORT FOR OCTOBER 1958 THROUGH MARCH 1959

Technical Report · Fri May 01 00:00:00 EDT 1959

OSTI ID:4199906

Data are presented frora a series of studies on radiation effects on protein solutions. Data are included on radical-combination reactions in the radiolysis of bonyl bonds in the radiolysis of aqueous proteins; the production of amide groups and ammonia in the radiolysis of aqueous proteins; and the irradiation of peptides in the solid state. High-energy protons and alpha particles from the 184-inch cyclotron were used for pituitary irradiation. One hundred three patients have been irradiated. Most of these patients had metastatic mammary carcinoma, and promising effects have been shown nn patients with this and various pituitary and hormonally dependent diseases. Peak doses of 14,000 to 30,000 rad have been delivered to the center of the pituitary. At the higher hypophysectomizing dose level, decreased pituitary- function and marked gross and microscopic damage to the pituitary have been demonstrated. Decrease in pituitary function and the consequent effects on the target and organs were manifested in depression of the thyroid iodine/sup 131/ uptake and decrease in 24- hour pituitary gonodotropins, urinary steroids, and estrogen excretion. These correlated well with clinical evidence of hypopituitarism. The biological effects or heavy ion beams were studied in mia. A new method involving external measurements of tions on yeast. The design is reported of a positron camera which employs a new principle for obtaining images of the distribution of positron-emitting isotopes in a human or other subject. Routine activities in health chemistry and health physics are summarized. A list of papers and reports prepared during the period is included. (For preceding period see UCRA.-8513.) (C.H.)

• Research Organization: California. Univ., Berkeley. Lawrence Radiation Lab.
• DOE Contract Number: W-7405-ENG-48
• NSA Number: NSA-14-000014
• OSTI ID: 4199906
• Report Number(s): UCRL-8705
• Country of Publication: United States
• Language: English

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ACETIC ACID-- ALBUMINS-- AMIDES-- AMINO ACIDS-- AMMONIA-- ATHEROSCLEROSIS-- BIBLIOGRAPHY-- BIOCHEMISTRY-- BLOOD VESSELS-- CAMERAS- - CARBON 14-- CARBONYLS-- CHEMICAL REACTIONS-- DECOMPOSITION-- DISEASES-- FREE RADICALS-- IRRADIATION-- ISOTOPES-- LIPIDS-- PEPTIDES-- PHOTOGRAPHIC FILM DETECTORS-- PLANNING-- POSITRONS-- PROTEINS-- RADIATION CHEMISTRY-- RADIATION EFFECTS-- RADIOLYSIS-- REACTION KINETICS-- SOLIDS-- SOLUTIONS-- WATER
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BIOLOGY AND MEDICINE