BIOLOGY AND MEDICINE SEMIANNUAL REPORT FOR APRIL THROUGH SEPTEMBER 1958

Technical Report · Tue Oct 21 04:00:00 EDT 1958

DOI:https://doi.org/10.2172/4281477· OSTI ID:4281477

Data are tabulated from studies of the long-term turnover rates for calcium-45 and strontium-90 in monkeys and rats Progress is reported in studies on the thyroid uptake and mammary tumor incidence in female rats as a function of dose of injected astatine211. Data are presented from studies on the radiation chemistry of solutions of pepsin. gelatin, chymotrypsin, yeast dehydrogenase, aqueous acetic acid --oxygen mixtures, oxygen-free formic acid solutions, and glysine -water systems at elevated temperatures. Encouraging results are reported following 340-Mev proton beam or 900-Mev alpha beam pituitary irradiation in patients with breast carcinoma, acromegaly. diabetes mellitus, and other conditdons that are under endocrine control through mediation of the pituitary Laboratory and clinical data indicating the degree of completeness of hypophysectomy are being collected on all patients. Studies were made of the thyroid function of animals subjected to intense alpha-particle or deuteron irradiation of the thyroid area. A method was developed for the separation of iodinated amino acids of the thyroid, and the method applied in tracer studies of the effect of pituitary irradiation on thyroid function in rats. Progress is reported in studies on: the effects of radiation on the permeability of yeast cells to sodium and potassium ions; applications of neutron-activation analysis in determining the constituents in samples of biological materials; the chemical properties and physiological effects of human urinary erythropcietin; the development of analytical metheds for the study of blood lipids; the role of heparin in lipid metabolism; the physiologi-cal role of lipoproteins in atherosclerosis and relationship to blood pressure and age; the effects of massive doses of a variety of estrogenic substances on the stimulatlon of liver phagocytic activity; the role of thymus in lymphocyte production; physiochemical studies of yeast metabollsm; the effects of pH and anoxia on growth and x-ray sensitivity of Escherichia coli- biological measurements of aging of man; and genetic studies on Drosophila. Routine radiological monitoring activities are summarized. A list is included of publications and papers presented during the period. (For preceding period see UCRL-8265.) (C.H.)

• Research Organization: California Univ., Berkeley, CA (US). Lawrence Radiation Lab.
• DOE Contract Number: W-7405-ENG-48
• NSA Number: NSA-13-007364
• OSTI ID: 4281477
• Report Number(s): UCRL-8513
• Country of Publication: United States
• Language: English

Related Subjects

ACIDITY-- BACTERIA-- ESCHERICHIA COLI-- OXYGEN-- QUANTITY RATIO-- RADIOSENSITIVITY-- VARIATIONS-- X RADIATION
ACROMEGALY-- ALPHA BEAMS-- CANCER-- DIABETES-- DISEASES-- EFFICIENCY-- GLANDS-- HORMONES-- MAMMARY GLANDS-- MAN-- MEDICINE-- PITUITARY GLAND-- PROTON BEAMS-- RADIOSURGERY-- RADIOTHERAPY-- SURGERY
ACTIVATION ANALYSIS-- BIOLOGY-- NEUTRON BEAMS-- SAMPLING-- USES
AGE-- ARTERIOSCLEROSIS-- ATHEROSCLEROSIS-- BLOOD CIRCULATION- - BLOOD VESSELS-- CHOLESTEROL-- DISEASES-- LIPIDS-- LIPOPROTEINS-- MAN-- PHYSIOLOGY-- PRESSURE-- PROTEINS-- VARIATIONS
AGE-- BIOLOGY-- MAN-- MEASURED VALUES-- QUANTITATIVE ANALYSIS
ALPHA BEAMS-- ANIMALS-- DEUTERON
BIOLOGY AND MEDICINE