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THE MECHANISM OF THE FORMATION OF MICRONECROTIC FOCI IN THE BONE MARROW OF ANIMALS ACTED ON BY PENETRATING RADIATION INVESTIGATED BY FLUORESCENCE AND ULTRA-VIOLET MICROSCOPY

Journal Article · · Biophysics (U.S.S.R.) (English Translation)
OSTI ID:4191220
;
In the bone marrow of irradiated animals micronecrotic foci are easily revealed by the methods both of fluorescence and of ultraviolet microscopy. In the fluorescence microscope micronecroses stand out against the general background of living cells with a continuous bright green fluorescence (when treated with acridine orange); in the ultraviolet microscope with stronger, more continuous absorption of ultraviolet light. Micronecrotic foci are rounded conglomerates of closely lying cells with a defirite type of injury (exfoliation and collapse of nuclear substance), as if immersed in a homogeneous medium. They are never found in the control animals. The combined uses of fluorescence and ultraviolet microscopy made it possible to approach an understanding of the mechanism of the formation of micronecroses. As a result of the action of iorizing radiation on part of the cells, exfollation and collapse of the nuclear substance occurs, with discharge from the cells of nucleic adids, and their combination modified both physically and chemically. This obviously lesds to cohesion of cells with the same kind of injuries. Additional irradiation of the micronecroses by ultraviolet light results in their disintsgration into separate cells. (auth)
Research Organization:
Central Scientific Research Inst. of Medical Radiology, Leningrad
NSA Number:
NSA-14-013591
OSTI ID:
4191220
Journal Information:
Biophysics (U.S.S.R.) (English Translation), Journal Name: Biophysics (U.S.S.R.) (English Translation) Vol. Vol: 4, No. 4
Country of Publication:
Country unknown/Code not available
Language:
English

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Related Subjects

ABSORPTION
ACRIDINE ORANGE
ANIMAL CELLS
ANIMALS
BIOLOGY AND MEDICINE
BONE MARROW
COLOR
DYES
FLUORESCENCE
GAMMA RADIATION
MICROSCOPY
NUCLEIC ACIDS
RADIATION INJURIES
ULTRAVIOLET RADIATION
X RADIATION