Solvent vapor sensor & bolus detector for radiosynthesis
Conference
·
OSTI ID:41888
- CERMEP, Lyon (France)
One of the key points in the Hamacher method of [{sup 18}F]FDG synthesis, in common with many other chemical reactions, is the need for an anhydrous state of the {sup 18}F/Kryptofix complex before addition of the mannose triflate. This is usually done by ensuring enough time elapses after the additions of acetonitrile for azeotropic distillation of the carbonate/K 2.2.2 solution, with the resulting possibility of overheating the dry kryptofix adduct. In this system, the entire [{sup 18}F]FDG synthesis is controlled by a Siemens Simatic S100 PLC; the fluorination takes place in an open Sigradur{reg_sign} vessel. The authors choose to automate this evaporation step with the control of this little vapor sensor, used otherwise to detect explosive atmospheres. The sensor is based on a miniature flammable gas sensor designed for detection of propane, butane, natural and {open_quotes}town{close_quotes} gas, using the platinum wire (pellistor) principle. Acetonitrile and organic flammable solvents are easily detected, the difference ({approximately} 30 mV) between the platinum sensing filament and compensating filament is measured and drives a K relay interfacing the Simatic PLC. Response time is within 3 seconds after complete disappearance of the solvent.
- Research Organization:
- Brookhaven National Lab., Upton, NY (United States)
- OSTI ID:
- 41888
- Report Number(s):
- BNL--61149; CONF-9309170--; ON: DE95006634
- Country of Publication:
- United States
- Language:
- English
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