Separation of [{sup 18}F]F{sup {minus}} from [{sup 18}O]H{sub 2}O on AV-17 anion-exchange resin. Regeneration of [{sup 18}O]H{sub 2}O irradiated in a cyclotron target
At the Institute of the Human Brain, [2-{sup 18}F]FDG is synthesized by a modified method using robotics. Owing to the scarcity and high cost of [{sup 18}O]H{sub 2}O, the robotic synthesis included a procedure for regenerating the enriched H{sub 2}O before the start of the synthesis by distilling it under a N{sub 2} stream from the reaction vessel containing Kryptofix 222 and K{sub 2}CO{sub 3}. The distillation was shown to regenerate up to 90% of the enriched H{sub 2}O from the target. This H{sub 2}O can then be used repeatedly to synthesize [2-{sup 18}F]FDG without decreasing the production of the desired nuclide or affecting the radiochemical yield or purity of the final product. However, this method was poorly reproducible owing to the remotely controlled synthesis and the peculiarities of H{sub 2}O evaporation. Therefore, the author developed an automated method for separating [{sup 18}F]F{sup {minus}} and regenerating the enriched H{sub 2}O that was based on domestic anion-exchange resins.
- OSTI ID:
- 136033
- Journal Information:
- Radiochemistry, Journal Name: Radiochemistry Journal Issue: 5 Vol. 36; ISSN RDIOEO; ISSN 1066-3622
- Country of Publication:
- United States
- Language:
- English
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