Detectors and transducers for target operation and automated P.E.T. chemistry

Conference · Sat Dec 31 04:00:00 EST 1994

OSTI ID:41886

Zeisler, S K; Ruth, T J; Rektor, M P; Gschwandtner, G A ^[1]

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1. TRIUMF, British Columbia (Canada)

Remote target operation as well as automated PET chemistry syntheses generally require feedback from the target or synthesis module to the computer control unit. Transducers such as pressure sensors and conductivity probes can be used to indicate the filling status of gas or liquid targets. Many radiopharmaceutical preparations involve the transfer of liquids containing radioactivity and the evaporation of solvents. The authors` goal was the automation of a production system for [{sup 18}F]-FDG consisting of a low-volume high pressure target and a synthesis module based on the TBA-HCO{sub 3} method by means of three recently developed devices: a non-invasive bolus detector to ensure complete filling of the water target, a small photodiode radiation detector to monitor trapping of the {sup 18}F-fluoride, on the ion exchange resin and its elution from the column, a thermistor probe to determine the endpoint of solvent evaporations from the reaction vessel. The detectors deliver a signal suitable for processing in the Optomux{trademark} control system. They show excellent reliability and have been successfully tested in [{sup 18}F]-FDG, [{sup 18}F]-FDOPA, and [{sup 13}N]-NH{sub 3} production.

• Research Organization: Brookhaven National Lab., Upton, NY (United States)
• OSTI ID: 41886
• Report Number(s): BNL--61149; CONF-9309170--; ON: DE95006634
• Country of Publication: United States
• Language: English

Related Subjects

40 CHEMISTRY
55 BIOLOGY AND MEDICINE
BASIC STUDIES
AUTOMATION
FLUORINE 18
FLUORINE COMPOUNDS
ION BEAM TARGETS
ISOTOPE PRODUCTION
LABELLING
ORGANIC COMPOUNDS
POSITRON COMPUTED TOMOGRAPHY
RADIOPHARMACEUTICALS