TOLERANCE OF IRRADIATED FATS (in German)
As is known, irradiation of polyene acids causes them to undergo similar changes as occur in auto-oxidation, and auto-oxidized fat can become toxic under certain conditions. Thus experiments were devised to study the effects of feeding fats irradiated by a substantially higher dose than is necessary for the sterilization or pasteurization of foodstuifs; to determine the radiation dose causing symptoms from irradiated fat; and the mechanism of the toxic effect. Sprague-Dawley rats were given soya oil, irradiated with 1-Mev electrons at 0, 2.5, 10, 50, and 100 Mrep doses. The fat made up 20% of the diet, which was supplemented with vitamins. With the 100-Mrep dose, after four weeks a depression in wt gain was observed which was connected with a significant loss in the nutritional efficiency of protein. After 3-month feeding, lethal toxicity was noted and after 6 months 18% of the animals died. Only 88% of the 100Mrep iriadiated oil was absorbed. At the 50-Mrep dose a significant disturbance in the liver function and decrease of plasma proteins were observed. From the 24th week on there was in increasing wt loss and mortality rate; after 32 weeks, 12 male rits out of 40 had died. Animals fed on 10-Mrep irradiated oil also showed a high mortality after 40 weeks. Other symptoms observed were: histologically detectible hypofunction of the thyroid gland, decreased body temperature, decreased oxygen consumption, and bradycardia. Other experiments with 100-Mrep irradiated fish oil showed similar results in 10 weeks. The cause of death could not be determined. Notable was the increased wt of liver, deposits of brown pigment in liver and spleen, which upon treatment with NaOH reacted for iron. Water consumption of rats did not change. Also noted was a marked hypoproteinemia accompanied by a characteristic change of the electrophoretic patterns of serum proteins; gamma globulins increased to 25.9%, as compared with 17.2% in the control group. (BBB)
- Research Organization:
- Johannes Gutenberg Universitat, Mainz
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-18-000040
- OSTI ID:
- 4178459
- Journal Information:
- Z. Ernaehrungswiss, Vol. Vol: 2; Other Information: Orig. Receipt Date: 31-DEC-64
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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Related Subjects
ACETYLENES
ALKENES
BLOOD PLASMA
DIET
ELECTRON BEAMS
ELECTROPHORESIS
FOOD
GLOBULINS
GLOBULINS-GAMMA
IRON
LIVER
METABOLISM
ORGANIC ACIDS
OXIDATION
OXYGEN
PIGMENTS
POLYENES
POLYMERS
PROTEINS
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RATS
SPLEEN
STERILIZATION
TEMPERATURE
THYROID
TOXICITY
VITAMINS