MARROW TRANSPLANTS IN LETHALLY IRRADIATED DOGS: THE EFFECT OF METHOTREXATE ON SURVIVAL OF THE HOST AND THE HOMOGRAFT

Journal Article · Tue Oct 01 00:00:00 EDT 1963 · Transplantation See Ishoku

DOI:https://doi.org/10.1097/00007890-196301040-00018· OSTI ID:4177047

Thomas, E D; Kasakura, S; Cavins, J A; Ferrebee, J W

Twenty dogs were given 1500 r whole-body irradiation and an infusion of homologous marrow. Ten dogs treated with methotrexate were compared with 10 dogs that received no drug therapy. The dogs given methotrexate showed an increased incidence of graft take, a decreased incidence of graft rejection, and an increased number of long-term survivors. (auth)

• Research Organization: Mary Imogene Bassett Hospital, Cooperstown, N.Y.
• Sponsoring Organization: USDOE
• NSA Number: NSA-18-000118
• OSTI ID: 4177047
• Journal Information: Transplantation See Ishoku, Journal Name: Transplantation See Ishoku Vol. Vol: 1; ISSN ISHTBS1
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AMMONIUM COMPOUNDS
ANTIMITOTIC DRUGS
BIOLOGY AND MEDICINE
BODY
BONE MARROW
CARBONATES
CRYSTALS
DIAGRAMS
DIFFRACTION
DOGS
DRUGS
FREQUENCY
IMMUNITY
INSTRUMENTS
IRRADIATION
LATTICES
LETHAL DOSE
METHOTREXATE
MIXING
NUMERICALS
OXALATES
PHOTOGRAPHY
PREPARATION
QUANTITATIVE ANALYSIS
RADIATION PROTECTION
SODIUM CARBONATES
SOLUBILITY
TABLES
TRANSPLANTS
URANYL COMPOUNDS
WATER
X RADIATION