EFFECT OF IONIZING RADIATION ON DEOXYRIBONUCLEIC ACIDS. II. THE MOLAR RELATIONSHIP OF DEOXYRIBONUCLEIC ACID BASES OF RAT SPLEEN AFTER THE ADMINISTRATION OF PYRIMIDINE DEOXYRIBOTIDES

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Folia Biologica (Prague) (Czechoslovakia)

OSTI ID:4174471

Palecek, E; Soska, J

Desoxycytidylic acid or thymidylic acid was adminIstered intraperitoneally to rats one day after they had been irradiated with a total-- body dose of 400 r. On the fifth day after irradiation the animals were killed and the ratio of the bases was determined in DNA isolated from the spleen. In rats to which desoxycytidylic acid was admiristered, the guanine/cytosine quotient and ths adenins/ thymine quotient were lower than in the irradiated controls. After the administration of thymidylic acid only the guanine/cytosine quotient was reduced. In no group, however. did all base relationships return to normal values. (auth)

• Research Organization: Inst. of Biophysics, Czechoslovak Academy of Sciences, Brno
• NSA Number: NSA-14-021311
• OSTI ID: 4174471
• Journal Information: Folia Biologica (Prague) (Czechoslovakia), Journal Name: Folia Biologica (Prague) (Czechoslovakia) Vol. Vol: 6; ISSN FOBLA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADENINE
BIOLOGY AND MEDICINE
BODY
CYTIDYLIC ACID
CYTOSINE
DNA
GAMMA RADIATION
GUANINE
IRRADIATION
NUCLEIC ACIDS
ORGANIC NITROGEN COMPOUNDS
RADIATION DOSES
RADIATION EFFECTS
RATS
SPLEEN
THYMIDYLIC ACID
THYMINE
VITAMIN B-4
VITAMINS
X RADIATION