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Effect of large doses of $sup 131$I-19-iodocholesterol on metapyralone- induced adrenal cortical hyperplasia in dogs

Journal Article · · J. Nucl. Med., v. 16, no. 10, pp. 928-932
OSTI ID:4173182
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The potential use of $sup 131$I-19-iodocholesterol to treat ACTH excess Cushing's disease was evaluated in the dog. Three normal female dogs were given LD$sub 50$ radiation doses of $sup 131$I-19-iodocholesterol without producing gross or histopathologically demonstrable change of the adrenals at autopsy 3 months later. The adrenal cortices of three dogs were made hyperplastic (to simulate the adrenal cortex in Cushing's disease) with ACTH and three with Metapyralone. In addition these six dogs were given LD$sub 50$ doses of $sup 131$I-19-iodocholesterol. Three months after treatment, the adrenal glands of the ACTH-treated dogs were not enlarged, the cortex was thicker than normal, and there were no changes attributable to irradiation. At 3 months, the Metapyralone- treated dogs had enlarged adrenals, widening of the adrenal cortex, and no necrosis or other changes attributable to irradiation. It is concluded that a therapeutic trial of $sup 131$I-19-iodocholesterol in the treatment of Cushing's disease is not indicated. (auth)

Research Organization:
Univ. of Michigan, Ann Arbor
NSA Number:
NSA-33-000990
OSTI ID:
4173182
Journal Information:
J. Nucl. Med., v. 16, no. 10, pp. 928-932, Journal Name: J. Nucl. Med., v. 16, no. 10, pp. 928-932; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

*ADRENAL GLANDS-- SCINTISCANNING
*IODINE 131-- SCINTISCANNING
560162* --Biomedical Sciences
Applied Studies--Radiation Effects--Radionuclide Effects--Internal Source--Animals
ACTH
CHOLESTEROL
DOGS
DRUGS
IODINE COMPOUNDS
LABELLED COMPOUNDS
N48620* --Life Sciences--Radionuclide Effects (Internal Source)--Animals
PATHOLOGICAL CHANGES
RADIONUCLIDE ADMINISTRATION
RADIONUCLIDE KINETICS
RESPONSE MODIFYING FACTORS