INVESTIGATION OF ACYLATED GEMINAL DIAMINES. PREPARATION OF $alpha$- AMINOACIDS LABELLED WITH $sup 14$C IN THE CARBOXYL GROUP
Journal Article
·
· Acta Chimica Academiae Scientiarum Hungaricae (Hungary)
OSTI ID:4169867
A new general method was developed for the synthesis of 1-C/sup 14/- amino acids. Essentially, the method consists of the exchange of the carboxyl group of the aminoacid by a C/sup 14/-carboxyl group through a reaction cycle. Starting from a given amino acid, first the N-phthaloyl, then from this latter the chloride, further the azide derivatives are prepared. Subjecting the azide derivatives to a Curtius decomposition, a carbamic acid derivative was obtained whose phthalimide group could be exchanged by a labeled cyanide-group. The hydrolysis of the formed nitrile derivative affords the desired labeled amino acid. It was possible to prepare DL-alanine-l-C/sup 14/ in a yield of 69.2%, l-C/ sup 14/ in yield of 43.5%. (auth)
- Research Organization:
- Central Research Inst. for Chemistry, Hungarian Academy of Sciences, Budapest
- NSA Number:
- NSA-18-000258
- OSTI ID:
- 4169867
- Journal Information:
- Acta Chimica Academiae Scientiarum Hungaricae (Hungary), Journal Name: Acta Chimica Academiae Scientiarum Hungaricae (Hungary) Vol. Vol: 8; ISSN ACASA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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Related Subjects
ALANINE
AMINO ACIDS
AROMATICS
AZIDES
CARBON 14
CARBONATES
CHEMICAL REACTIONS
CHEMISTRY
CRACKING
CYANIDES
DECOMPOSITION
DECONTAMINATION
ENERGY
FUEL ELEMENTS
HYDROLYSIS
IMPREGNATION
IONIZATION
IRRADIATION
ISOTOPIC EXCHANGE
LABELLED COMPOUNDS
LIQUIDS
LOSSES
MELTING POINTS
NITRIDES
NITRILES
ORGANIC NITROGEN COMPOUNDS
PAPER
PETROLEUM
PHENYL RADICALS
PHTHALIC ACID
POLYMERIZATION
POLYMERS
PREPARATION
PRODUCTION
PROPULSION
RADIATIONS
REACTION KINETICS
RESINS
SOLIDS
STEAM
THERMODYNAMICS
USES
VALINE
VINYL RADICALS
AMINO ACIDS
AROMATICS
AZIDES
CARBON 14
CARBONATES
CHEMICAL REACTIONS
CHEMISTRY
CRACKING
CYANIDES
DECOMPOSITION
DECONTAMINATION
ENERGY
FUEL ELEMENTS
HYDROLYSIS
IMPREGNATION
IONIZATION
IRRADIATION
ISOTOPIC EXCHANGE
LABELLED COMPOUNDS
LIQUIDS
LOSSES
MELTING POINTS
NITRIDES
NITRILES
ORGANIC NITROGEN COMPOUNDS
PAPER
PETROLEUM
PHENYL RADICALS
PHTHALIC ACID
POLYMERIZATION
POLYMERS
PREPARATION
PRODUCTION
PROPULSION
RADIATIONS
REACTION KINETICS
RESINS
SOLIDS
STEAM
THERMODYNAMICS
USES
VALINE
VINYL RADICALS