BIOLOGICAL EFFECTS OF Sr$sup 90$ IN MINIATURE SWINE. I. EXPERIMENTAL DESIGNS AND PRELIMINARY OBSERVATIONS
The experimental design and preliminary results are described for a study undertaken to estimate the maximum permissible daily intake for Sr/sup 90/ in man and his offspring by means of daily feeding of this radioisotope to miniature swine. Extrapolation of these experimental results to man will be attempted by the study of comparative toxicity of Sr/sup 90/ and Ra/ sup 226/ in these animals, Results after nine months of daily ingestion of 1, 5, or 25 mu c of Sr/sup 90/ are inconclusive. No significant observable effects were noted in any of the adult feeding levels, The first generation offspring from the 25 mu c adult swine, however, showed a slight trend toward lower birth and weaning weights, and a tendency toward microcytic anemia. The comparative toxicity animals, at one month following injection of their respective radioisotopes, evidenced no skeletal pathology as determined by clinical and x- ray examination. Certain blood constituents in these animals, however, showed tendencies toward lower values when compared to the controls. (auth)
- Research Organization:
- General Electric Co. Hanford Atomic Products Operation, Richland, Wash.
- DOE Contract Number:
- AT(45-1)-1350
- NSA Number:
- NSA-14-022753
- OSTI ID:
- 4167410
- Report Number(s):
- HW-63499
- Country of Publication:
- United States
- Language:
- English
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